PRAETORIAN-COVID

A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease

VALSARTAN ARB COVID PLACEBO COVID-19 PRAETORIAN PRAETORIAN-COVID TRIAL STUDY PRAETORIAN PRAETORIAN PRAETORIAN PRAETORIAN PRAETORIAN PRAETORIAN PRAETORIAN COVID COVID COVID COVID COVID COVID COVID PRAETORIAN-COVID PRAETORIAN-COVID PRAETORIAN-COVID PRAETORIAN-COVID VALSARTAN COVID VALSARTAN COVID VALSARTAN COVID VALSARTAN COVID VALSARTAN COVID bloeddruk blood pressure hypertension hypertensie corona virus valsartan bloeddruk blood pressure hypertension hypertensie corona virus valsartan bloeddruk blood pressure hypertension hypertensie corona virus valsartan bloeddruk blood pressure hypertension hypertensie corona virus valsartan bloeddruk blood pressure hypertension hypertensie corona virus valsartan

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The primary objective of the PRAETORIAN-COVID study is to investigate the effect of valsartan compared to placebo in hospitalized SARS-CoV-2-infected patients on the first occurrence of ICU admission, mechanical ventilation or death, within 14 days of randomization.

The research ethics committee of the Radboud University Medical Center (CMO Arnhem-Nijmegen) has passed a positive judgment on the study on the basis of the Dutch Code of conduct for health research, the Dutch Code of conduct for responsible use, the Dutch Personal Data Protection Act and the Medical Treatment Agreement Act.

The trial is registered at Clinicaltrials.gov (NCT04335786, 2020) for more detailed information on the protocol.

Principal investigator: R.R.J. van Kimmenade, MD, PhD

Coordinating investigator: D.H.F. Gommans, MD, PhD

VALSARTAN ARB COVID PLACEBO COVID-19 PRAETORIAN PRAETORIAN-COVID TRIAL STUDY PRAETORIAN PRAETORIAN PRAETORIAN PRAETORIAN PRAETORIAN PRAETORIAN PRAETORIAN COVID COVID COVID COVID COVID COVID COVID PRAETORIAN-COVID PRAETORIAN-COVID PRAETORIAN-COVID PRAETORIAN-COVID VALSARTAN COVID VALSARTAN COVID VALSARTAN COVID VALSARTAN COVID VALSARTAN COVID